The New Class Of Anti Diabetic Drugs - 2008 Words

Abstract Glitazones are the new class of anti-diabetic drugs that are the first to be able to manage glycaemia goals. Troglitazone was first approved for the market in 1997, but it was withdrawn from the market by 2000. After the withdrawal of troglitazone, rosiglitazone and pioglitazone were introduced in 1999 as potentially safer alternatives. However, currently rosiglitazone is under black box warning for increased risk of cardiovascular disease and pioglitazone is in a nutshell as the drug required more investigation. In this review, the potential ability to predict the adverse drug reactions (ADRs) are examined. If it is possible to predict ADRs, should it be done in the future. Introduction Millions of people worldwide are affected due to diabetes, 90% of them having type 2 diabetes mellitus (non-insulin dependent). Since 1921, drug therapy has been improved minutely and in 1950s the antidiabetic sulphonamides and biguanides has been introduced. Therefore, the arrival of â€Å"glitazone† or thiazolidinediones is an important event (14). Thiazolidinediones are being developed for the treatment of type 2 diabetes mellitus and insulin resistance. Thiazolidinediones binds and activate the peroxisome proliferator-activated receptor ÃŽ ³ (PPAR), a nuclear receptor that regulates the several genes which are involved in metabolism. The PPAR ÃŽ ³ controls lipid storage, insulin sensitization and adipocyte differentiation. Besides the metabolic activities, thiazolidinediones also haveShow MoreRelatedThe Problem And Its Background Essay1123 Words   |  5 PagesInsulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage. 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Out of the three drugs there was a study to show the potency between metformin and buformin.5 Although buformin is not used in the United States due to it’s high incidenceRead MoreClass Iv : Type 2 Diabetes1723 Words   |  7 PagesCLASS IV: THIAZOLIDINEDIONES Type 2 diabetes is mainly associated with abnormalities in any of the following 3 basic pathophysiologic abnormalities: †¢ Impaired insulin secretion †¢ Excessive hepatic glucose production †¢ Insulin resistance in skeletal muscle, liver and adipose tissue.9 The thiazolidinediones are a unique class of agents that improve the third parameter, and are therefore also called as the â€Å"Insulin sensitizers†. 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