The New Class Of Anti Diabetic Drugs - 2008 Words

Abstract Glitazones are the new class of anti-diabetic drugs that are the first to be able to manage glycaemia goals. Troglitazone was first approved for the market in 1997, but it was withdrawn from the market by 2000. After the withdrawal of troglitazone, rosiglitazone and pioglitazone were introduced in 1999 as potentially safer alternatives. However, currently rosiglitazone is under black box warning for increased risk of cardiovascular disease and pioglitazone is in a nutshell as the drug required more investigation. In this review, the potential ability to predict the adverse drug reactions (ADRs) are examined. If it is possible to predict ADRs, should it be done in the future. Introduction Millions of people worldwide are affected due to diabetes, 90% of them having type 2 diabetes mellitus (non-insulin dependent). Since 1921, drug therapy has been improved minutely and in 1950s the antidiabetic sulphonamides and biguanides has been introduced. Therefore, the arrival of â€Å"glitazone† or thiazolidinediones is an important event (14). Thiazolidinediones are being developed for the treatment of type 2 diabetes mellitus and insulin resistance. Thiazolidinediones binds and activate the peroxisome proliferator-activated receptor ÃŽ ³ (PPAR), a nuclear receptor that regulates the several genes which are involved in metabolism. The PPAR ÃŽ ³ controls lipid storage, insulin sensitization and adipocyte differentiation. Besides the metabolic activities, thiazolidinediones also haveShow MoreRelatedThe Problem And Its Background Essay1123 Words   |  5 PagesInsulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage. (Daisy, et al., 2009) Numerous natural drugs are used in traditional medicine as antidiabetics, and several active compounds have been identified by in vivo bioassay using alloxan or Streptozotocin (STZ) induced diabetes. In line with this, the researchers decided to study an alternative wayRead MoreTypes Of Cancer Of The Uterus, Uterine Sarcomas And Endometrial Carcinomas869 Words   |  4 Pagescancer are surgery, radiation therapy, hormonal therapy and chemotherapy.4 Expanding on treatment, there is a growing body of evidence that suggests the anti-diabetic class, biguanides, may have effective anti-cancer properties against endometrial cancer. 2 The three drugs included in this class are metformin, buformin and phenformin. Out of the three drugs there was a study to show the potency between metformin and buformin.5 Although buformin is not used in the United States due to it’s high incidenceRead MoreClass Iv : Type 2 Diabetes1723 Words   |  7 PagesCLASS IV: THIAZOLIDINEDIONES Type 2 diabetes is mainly associated with abnormalities in any of the following 3 basic pathophysiologic abnormalities: †¢ Impaired insulin secretion †¢ Excessive hepatic glucose production †¢ Insulin resistance in skeletal muscle, liver and adipose tissue.9 The thiazolidinediones are a unique class of agents that improve the third parameter, and are therefore also called as the â€Å"Insulin sensitizers†. Insulin resistance syndrome also called as Syndrome X is caused by aRead MoreClass Iv : Type 2 Diabetes1722 Words   |  7 PagesCLASS IV: THIAZOLIDINEDIONES Type 2 diabetes is mainly associated with abnormalities in any of the following 3 basic pathophysiologic abnormalities: †¢ Impaired insulin secretion †¢ Excessive hepatic glucose production †¢ Insulin resistance in skeletal muscle, liver and adipose tissue.9 The thiazolidinediones are a unique class of agents that improve the third parameter, and are therefore also called as the â€Å"Insulin sensitizers†. Insulin resistance syndrome also called as Syndrome X is caused by aRead MoreInternational Conference On Harmonization Guidelines1612 Words   |  7 Pagesindustrialized countries. CCDSS has reported that in adult people who are over 20 years old, the prevalence of diabetes mellitus rate was 8.7% (95% CI: 8.72-8.74%), indicating one diabetic patient in 11 healthy Canadians A , B[3, 14]. The common sort of diabetes disease is Diabetes mellitus type 2 (T2DM) that covers the 90% diabetic cases. It is a metabolic disorder that is determined by hyperglycemia (high level of blood sugar) as a result of resistance to insulin in cell membrane and relative lack ofRead MoreDiabetes Mellitus Essay1600 Words   |  7 Pagesand if the level of fasting glucose happens to range between 5.5 and 7.7mmol/L, it indicates presence of glucose tolerance. Furthermore if the blood glucose level concentration comes out to be greater than 11.mmol/L, it confirms that a person is diabetic. ((Dowse GK, Gareebo H Zimmet PZ 2009). MANAGEMENT AND RESPONSE TO EXCERCISE: MEDICAL MANAGEMENT: Vitamins are prescribed as they help in regulation of blood glucose levels and child is asked to indulge himself in activities that make him happyRead MoreThe Herbal And Dietary Supplement Market1501 Words   |  7 Pagesimportance of food in treatment and prevention of diseases since regular consumption of synthetic drugs sometimes cause organ failure and so many other effects. Again, consumers have the belief that food like substances are either harmless or less toxic as compared to conventional drugs, furthermore nutraceuticals are cheaper and are safe with regards to avoiding the side effects associated with drugs (Tapans et al., 2008). CLASSIFICATION Nutraceuticals can be isolated nutrients herbal products, dietaryRead More2.2 Flavonoid in Pharmaceutical Flavonoids are widely distributed in plants, fulfilling many1000 Words   |  4 PagesFlavonoids, which are polyphenolic compounds, are a class of plant secondary metabolites possessing a broad spectrum of pharmacological activity including anti-cancer activities. Among the various natural products, flavonoids have attracted much attention due to their remarkable spectrum of pharmacological activities such as antioxidant, antimutagenic, antibacterial, antiangiogenic,anti-inflammatory, antiallergic, modulators of enzymatic activities and anti-cancer activity. Flavonoids have been found actRead MoreEssay on Diabetes Mellitus1282 Words   |  6 Pagestype 1 diabetes mellitus involves genetic susceptibility and environmental factors. Type 1 diabetes mellitus connects with at least 50 % of the genetic susceptibility to the genes of major histocompatibility complex (MHC) that are important in coding class 2 human leukocyte antigens (Funk, 2010). According to Abbas et al. (2010), there is evidence that environmental factors particularly viral infection can cause the trigger of Islet cell destruction in type 1 diabetes mellitus through three mechanismsRead MoreHerbal medicine is the traditional medical practice and it’s an important part of medicine to this1200 Words   |  5 Pagesa yearly basis, 0.5% of the population is diagnosed with cancer. It can be treated with chemotherapy, immunotherapy, targeted therapies etc., but all these have side effects and that is why botanical treatment turns useful. There were 14.1 million new cancer cases, 8.2 million cancer deaths and 32.6 million people living with cancer (within 5 years of diagnosis) reported by IARC in 2012 worldwide. Breast and ovarian cancer are the major cause of cancer death in American women, with an estimated 44

Study on Indian Government Debts and Deficits and Its...

[pic] Study on government deficits and debts in India. How do government debt-deficit sustainability issues hinder India’s growth Abstract Emerging nation India has high hopes of becoming a developed nation. In recent time Indian economy is considered as the fastest growing economy hence there are certain drawbacks such as the government deficits, debts which hinder India from achieving their goal. Development of nation is based on several factors and its more important for every nation to encourage changes, although metamorphic changes have been brought about in the Indian economy every now and then which has seen India emerging as one of the fastest growing countries in the world but on the other hand one of the most embarrassing†¦show more content†¦There are various types of debts which companies consider to finance its projects and operations. These may be secured or insecure debts, further categorised into public and private debts. A basic loan is the simplest form of debt. Some of the debts are named as following †¢ Bank Overdraft †¢ Any loan †¢ Working Capital †¢ Bill Discounting â⠂¬ ¢ Financing for project †¢ Cash credit †¢ Cash on Assets. DEFICITS Again in simple words it is the difference between money earned and money spent, here in terms of government deficits it is considered as the annual federal budget and accordingly deficit is the amount that nation’s federal government borrows each year. Its the difference between what the federal government spends and the revenue it receives during a particular year. A governments deficit can be measured with or without including the interest it pays on its debt. 2. What are government debts and deficits? As discussed above a deficit occurs when expense is more than income. In case of government, a government deficit occurs when government has spent more than the revenue collected in particular financial year, in other words its also knows as government budget deficit. These revenues consist of the money that government collects from its public in form of income tax, excise duties, and social insurance contribution, along with different other non-tax revenues such as foreign aid. On the other handShow MoreRelatedIndian Fiscal Policy Impacts9621 Words   |  39 Pages Batch 2010-12 Student’s Signature Azhar Shokin Topic: - Impact of Fiscal Policy on Indian Economy Contents * Introduction * Literature Review * Research * Article * Analysis * Data and Methodology * Main Findings * Conclusion * Recommendations * References Impact of Fiscal Policy on Indian Economy Introduction In economics, fiscal policy is the use of government expenditure and revenue collection to influence the economy. Fiscal policy can be contrastedRead MoreExport Led Growth of India3114 Words   |  13 PagesEconomic Growth of India Economic Growth is one of the foremost goals of policymakers throughout the world. Every country has varied strategies across the time for pursuing this objective. One amongst all the strategy is the export-led growth. This strategies directly associated with East Asian countries during the recent period. Export-led growth model appears to have become a desirable for many developing countries across the globe in recent years. Following the Asian financial crisis of 1997–1998Read MoreIndia and China Comparative Economic Analysis5875 Words   |  24 Pagesareas of economic and social indicators, where the score card is continually changing. Infact, the strengths of India are very often the weaknesses of China and the strengths of China are the weaknesses of India. Notwithstanding their recent economic growth stories, each has its weak point— regional conflicts, pov ¬erty, linguistic and religious divisions for India; the contradiction between a capitalist economy and C ommunist politics, growing regional divide and growing unemployment for China. Both areRead MoreCritical Analysis of New Indian Economic Policy5290 Words   |  22 PagesINTRODUCTION TO INDIAN ECONOMY The economy of India as per the GDP is the eleventh largest economy in the world and by purchasing power parity the fourth largest. Following strong economic reforms from the socialist inspired economy of Indian nation before the time of independence, the country began to develop a fast-paced economic growth, as free market principles were initiated in 1990 for international competition and foreign investment. India is an emerging economic power with a very largeRead MoreEconomic Environment in India9561 Words   |  39 PagesFeatures of Indian Economy, India in World Economy. Economic Policies : Agriculture Policy, Industrial Policy, Commercial Policy Fiscal Policy. Economic Planning : Meaning, Importance, Objectives Techniques of Planning. II. III. Section – B I. Significance of Agriculture in Indian Economy and New Agriculture Strategy. 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As per government norms, if FDI is allowed then 50% of the total FDI has to be invested in backend infrastructure. This will improve the processing, distribution, packing amp; logistics in agro-sector. Thus a huge change in Retail-business is possible. This will have a positive impact on the Indian Economy growth. Increase of FDI in Retail also help full for providing employment. But there are also some drawbacksRead Morefundamental and technical analysis of banking stocks11699 Words   |  47 Pagesstocks† is the systematic study of the performance of banking companies stock’s in stock market and future value of the share price with help of fundamental analysis and technical analysis. While decision in share price based on actual movement of shares price measured mor e in money percentage term nothing else. In the Analysis, calculations are based on FACTS not on HOPE. The subject of Analysis is to determine future share price movement with the help of RATIO ANALYSIS, STUDY OF GRAPH. 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COCEPTUAL ANALYSIS †¢ Indian banking system †¢ The problem of non performing assets †¢ Reasons for turning an asset in NPA †¢ Trend in NPAs 34 – 52 7. FINDINGS AND CONCLUSIONS †¢ Impact of NPAs †¢ Difficulties with NPA †¢ Key structural changes †¢ Reporting format of

Love An Inexpressible and Indescribable Feeling Free Essays

Love is an indescribable and inexpressible feeling. It can affect a person to the point of recklessness. Once a soul has realized its counterpart in another, the effects can cause one to surrender themselves completely. We will write a custom essay sample on Love: An Inexpressible and Indescribable Feeling or any similar topic only for you Order Now Judgment becomes clouded and rationality no longer exists. In the end, all that remains is pure, indefinable emotion. This emotion is what fuels the person. Love is why almost everybody on Earth looks forward to tomorrow. Those who lack it will try to look for it. Those who have it, will work themselves to the bone Just for the ones they love. It is the best possible feeling Christopher Final Essay Love is an inexpressible and indescribable feeling. It can affect a person to the point of recklessness. Once a soul has recognized its counterpart in another, the effects can cause one to surrender themselves completely. Judgment becomes clouded and rationality no longer exists. In the end, all that remains is pure, indefinable emotion. This indefinable emotion is what fuels the person. Love is the reason why almost everybody on Earth looks forward to tomorrow. Those who do not have it, tries to look for it. Those who have it, will work themselves to the bone Just for the ones they love. It is the best possible feeling one could ever feel. While love seems like a splendid thing, it also has its flaws. The most well-known negative thing that comes along with love is Jealousy. Jealousy is a special form of emotive Kim k unemotional anxiety, which occurs due to the lack of a sense of security in relation to the one who is loved. The Jealousy directed to a third party, I. E. , the competitor who is perceived as the rival for the affection of the person who is loved. Jealousy is n emotion having components of both anger and fear commonly found in children. It originates from the lack of a sense of security for the affections of one who is loved and more attended to. The play, A Midnight Summer’s Dream is about several couples in love and the problems that cause relationships to crumble like dominoes, one after another. Shakespeare is mainly focusing on the crazy things that people do when they are in love. People tend to break the shackles of normalcy and common sense and do things for their own madness. In the play, A Midnight Summer’s Dream, Shakespeare uses the shifting of the peoples’ personalities to emphasize what love could do to people. As a person falls deeper in love, he or she becomes blind to things that happen around them and could care less about anything else except their own love affairs. Shakespeare portrays this in A Midsummer Night’s Dream when Helena accuses Demerits of killing Lessened and asks him if he has killed Lessened. The shift in her personality reveals the interference of love since she starts blaming others groundlessly. Shakespeare uses this to show how people react to problems hat involve love and how foolish their actions are. Another major problem caused by love is rivalry and how easily friendship can be crumbled when it comes to the issue of love. When Hermit enters the scene while Demerits and Lessened are with Helena, Hermit blindly enters and is questioned by Helena because Demerits and Lessened both originally liked Hermit. Therefore, she thinks it is a trick and they are when her close friend is involved. Thus, Helena starts the argument which causes her friendship with Hermit to crumble. Shakespeare is clearly showing the message of owe the common nature of people causes them to make rash decisions and change personalities because of love. People in love will see the world in a different perspective, they become so obsessed with their love to the extent that their world revolves around the person they love. This type of love can cause trouble, especially when deep and intense. This is seen almost every day in real life. For example, heartbroken girlfriends throwing pots down the window and locking their boyfriends out is the first image that comes to mind when thinking of Jealousy. How to cite Love: An Inexpressible and Indescribable Feeling, Papers

Moment of Discovery Essay Example For Students

Moment of Discovery Essay The high-pitched sound of a horn beeping in the driveway caught my attention. I looked up and sprinted to the window. Peering through the window, I heard Michaelas mother shout from downstairs, Jeana! Your mothers here!   Quickly, I gathered my scattered belongings, shoved them into my bag, said my goodbyes, and slammed the door behind me. I scampered down the stairs rapidly, knowing my mother was in a hurry. When I finally reached the car, I was struggling to catch my breath. I opened the door and plopped down on the seat, tossing my bag in the back seat. Immediately, the car began moving backward. I buckled my seatbelt and tried to get comfortable. After a few moments passed, my mother spoke up and asked, What did you do today?   OH!   I replied in excitement, We went swimming, and played a couple of games. It was a lot of fun. How was your day?   Well,   my mother responded with a pause, Do you remember when your cousin Jenny went through chemotherapy for her Non-Hodgkins Lymphoma seven years ago?   I sat there with no answer, and suddenly began to recall way back when I was seven years old. Memories came racing back into my mind. I remember going to the hospital to visit her, and my parents telling me she was very, very sick. They told me we had to be extremely careful not to bring germs into her room. Her once luscious, long, dark brown hair was gone. She looked exhausted, like she could give up at any moment, but she didnt. Cords were hooked all over her body supplying medicine to make her better. She was dressed in a hospital gown, which was not the most flattering thing in the world, but somehow she still looked beautiful. She was smiling through it all, showing everyone around her that she was strong enough to beat cancer. Although, we all knew deep, down inside, that this was the hardest experience she has ever gone through. It was not just going to go away over night like the common cold or flu. She had to fight for her life to overcome this disease, and she did, at least so I thought. Yes,   I answered, no longer with excitement knowing something was terribly wrong. The doctors told us that the tumors stopped growing and were no longer malignant. But, this time the cancer came back stronger, and progressing faster than before. The only option she has is to have a stem cell transplant, which will hopefully cure her. Because of this, she will have to stay in the hospital for a month while she undergoes extensive chemotherapy in order to prepare for the stem cell transplant.   Why does she have to get ready for the stem cell transplant? How come they cant just do it now?   I questioned. They need to lower her immune system down to basically nothing before they do the transplant, so her body doesnt fight the transplant off. This is very dangerous because she can easily pick up other infections. But, all we can do is hope and pray for the best.   I sat in the car in silence, taking all of this in. I looked out the window trying to avoid eye contact with my mother; I knew she was crying and I felt as if I would begin at any moment. I didnt understand why bad things happen to such kind-hearted, loving people. This car ride changed my mood from upbeat and carefree to sad and confused. We didnt know how this treatment would react with her body, and for all we knew it could lead to death. .u5a7623cb13a958ce6ff24679e705d6a3 , .u5a7623cb13a958ce6ff24679e705d6a3 .postImageUrl , .u5a7623cb13a958ce6ff24679e705d6a3 .centered-text-area { min-height: 80px; position: relative; } .u5a7623cb13a958ce6ff24679e705d6a3 , .u5a7623cb13a958ce6ff24679e705d6a3:hover , .u5a7623cb13a958ce6ff24679e705d6a3:visited , .u5a7623cb13a958ce6ff24679e705d6a3:active { border:0!important; } .u5a7623cb13a958ce6ff24679e705d6a3 .clearfix:after { content: ""; display: table; clear: both; } .u5a7623cb13a958ce6ff24679e705d6a3 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u5a7623cb13a958ce6ff24679e705d6a3:active , .u5a7623cb13a958ce6ff24679e705d6a3:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u5a7623cb13a958ce6ff24679e705d6a3 .centered-text-area { width: 100%; position: relative ; } .u5a7623cb13a958ce6ff24679e705d6a3 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u5a7623cb13a958ce6ff24679e705d6a3 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u5a7623cb13a958ce6ff24679e705d6a3 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u5a7623cb13a958ce6ff24679e705d6a3:hover .ctaButton { background-color: #34495E!important; } .u5a7623cb13a958ce6ff24679e705d6a3 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u5a7623cb13a958ce6ff24679e705d6a3 .u5a7623cb13a958ce6ff24679e705d6a3-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u5a7623cb13a958ce6ff24679e705d6a3:after { content: ""; display: block; clear: both; } READ: Rosa parks EssayThis car ride could not be over fast enough. I just wanted to be in my bed, escaping from the world for a bit, while I sorted things out in my head. My cousin, Jenny, is by far one of the biggest role models in my life. She fought cancer off, not once, but twice. When I was seven years old, I didnt exactly understand how cancer would change her life. I didnt know it could come back again, even stronger than the first time. I thought once it was gone, it would always be gone. Cancer has brought my family closer together; we didnt understand how much we needed each other until adversity struck. We learned to take one day at a time and not rush things. Being positive through all this commotion made me into a stronger person. We learned to laugh through the hard times and never take a moment together for granted. Tears watered our frowns blooming forth smiles and drowned our sobs, bringing forth laughter. We were each others support group, always there when one of us was down. This experience has made me into the person I am today. I learned to appreciate little moments with loved ones, and never take a person for granted because you never know when reality will hit.